It is a benign tumor affecting this gland which results in collateral damage such as the overproduction of hormones or the compression of adjoining brain structures once the tumor has reached a significant size.
For more than 30 years Albert Beckers has been fascinated by giants and has studied the causes of gigantism. The results of that study were published in in the Journal of Clinical Endocrinology and Metabolism JCEM 1 see article: Hypophyseal tumors, the search for the genes has begun! The researchers at NIH therefore pointed out the location of the region of the X chromosome where the duplication of the 11 genes was observed to the researchers in Liege.
Albert Beckers explains. Pituitary Adenomas : Analysis in 73 families. Metab, 92 5 , As a researcher into ageing, for me the important question is why does height, such a useful day-to-day feature, and arguably an evolutionary advantage for our hunter-gatherer ancestors on the savannah, seem to count against us? There are two good hypotheses here, one arguing the case for nature and the other for nurture — but it may be that they are linked.
On the nurture, environmental factors side of the argument, there has been a lot of research conducted recently on the idea that reduced calorie intake eating less can correlate with greater longevity. Essentially, faced with restricted quantities of available food, animals tend to live longer.
We have found good evidence for this in worms, mice, dogs, monkeys, and there are even suggestions of the same effect in humans. Indeed, children who lived through the Second World War and rationing show a bump in longevity statistics.
Why does this matter? Because these calorie restricted worms, mice, monkeys and children are also shorter than their well-feed peers. So average height across a population is a rough marker of calorie availability during childhood and development, which is a factor that decides height in adulthood. On the nature side of the argument, it might seem obvious but genetics dictates height as well.
Even my above average height makes me the shortest member of my family, with a brother, mother and father who are all taller than me. In particular, the conveniently named and easy to remember gene Forkhead family, O subclass, type 3 gene FOXO3 , has a common variation that is associated with longevity in worms, in flies, and in human centenarians.
The Postgraduate Medical Journal of the British Medical Journal suggests the hormones make the heart thicker in disproportion to its blood-pumping chambers. Taller people need not be worried. HT Gizmodo. More: The legal age you can get married around the world, mapped. And researchers may have found why.
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