If you drink too much alcohol over a long period of time, your liver can become damaged. This is because alcohol produces a lot of toxins when it breaks down. Your liver can become overworked from having to remove these toxins all the time. Cymbalta can also potentially cause liver damage.
Drinking while you take Cymbalta could increase this risk. This is especially true if you drink heavily. Heavy drinking is usually defined as three or more alcoholic drinks per day. If your doctor allows it, you should discuss how much is a safe amount of alcohol while you take this drug.
One of the conditions that Cymbalta treats is depression and the symptoms that go along with it. However, this drug can sometimes also cause depression and anxiety symptoms. Alcohol interrupts communication pathways in the brain which can affect the way the brain works and can cause changes in mood and behavior. These changes may make these symptoms worse.
It can also make your anxiety worse. Alcohol can affect the quality of your sleep, which can contribute to worsening depression. Further, long-term heavy alcohol use while taking an antidepressant such as Cymbalta can make your antidepressant less effective.
If you start to have problems with your weight while taking duloxetine, talk to your doctor or pharmacist. During the first few days of taking duloxetine, it might be best to stop drinking alcohol until you see how the medicine affects you.
There's no firm evidence to suggest that taking duloxetine will reduce fertility in either men or women. But speak to a pharmacist or your doctor before taking it if you're trying to get pregnant.
Speak to your doctor if you're planning to get pregnant while taking duloxetine. Duloxetine will not affect any type of contraception, including the combined pill or emergency contraception. Some people cannot concentrate properly while they're taking duloxetine. When you first start taking duloxetine, it's a good idea to stop driving and cycling, and avoid using machines or tools, for the first few days until you know how this medicine makes you feel.
Cannabis can affect the levels of duloxetine and make you more likely to get side effects. Talk to your doctor if you think you might use recreational drugs while taking duloxetine. Page last reviewed: 31 January Next review due: 31 January Duloxetine On this page About duloxetine Key facts Who can and can't take it How and when to take it Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions.
About duloxetine Duloxetine is an antidepressant medicine. Duloxetine comes as capsules and is only available on prescription. Help us improve our website Can you answer a quick question about your visit today? Duloxetine normally takes 2 to 4 weeks to work. It may take longer if you're taking it for nerve pain. Common side effects include feeling sick, a dry mouth, headache, constipation and feeling sleepy. These side effects are usually mild and go away after a couple of weeks. If you and your doctor decide to take you off duloxetine, your doctor may recommend reducing your dose gradually to help prevent extra side effects.
Duloxetine is also called by the brand names Cymbalta and Yentreve. Duloxetine can be taken by adults aged 18 years and over. For stress urinary incontenince, duloxetine can only be used by women.
To make sure it's safe for you, tell your doctor if you: have had an allergic reaction to duloxetine or any other medicines in the past have kidney or liver problems have a heart problem are taking or have taken other medicines for depression within the last 14 days have an eye condition called glaucoma - duloxetine can increase the pressure in your eye have or have had fits, manic episodes or bipolar disorder bruise easily are trying to become pregnant, are already pregnant, or you're breastfeeding.
How much will I take? How much you take will depend on what you're taking it for: depression - the starting dose is 60mg a day and can be increased to mg a day anxiety - the starting dose is 30mg a day and can be increased to 60mg a day nerve pain - the starting dose is 60mg a day and can be increased to 60mg twice a day stress urinary incontinence - the starting dose is 20mg twice a day and can be increased to 40mg twice a day after 2 weeks What if I forget to take it?
If you usually take duloxetine: once a day - take the missed dose as soon as you remember, unless it's less than 12 hours until your next dose, in which case skip the missed dose twice a day - take the missed dose as soon as you remember, unless it's less than 4 hours until your next dose, in which case skip the missed dose Never take 2 doses at the same time to make up for a forgotten one.
If you forget doses often, it may help to set an alarm to remind you. What if I take too much? Urgent advice: Call your doctor straight away if you take too much duloxetine and:. Common side effects These side effects happen in more than 1 in people. These are not all the side effects of duloxetine. For a full list, see the leaflet inside your medicines packet. Information: You can report any suspected side effect to the UK safety scheme.
What to do about: difficulty sleeping - try taking duloxetine first thing in the morning headaches - make sure you rest and drink plenty of fluids. Duloxetine is a drug that requires careful attention and close monitoring.
Taking Cymbalta while pregnant , receiving treatment despite the potential side effects, and having a glass of wine at dinner while on Duloxetine — all involve certain risks. It is generally not recommended to mix alcohol and Cymbalta.
This medication poses a threat to patients with existing liver problems, and frequent or excessive drinking significantly increases the risk of severe liver damage when taken with Duloxetine.
Drinking may also disrupt the treatment and reduce the therapeutic effects of Duloxetine. At the same time, taking Cymbalta and drinking a small amount of spirits once might not adversely affect the person. The level of risk increases along with the amount of ingested alcoholic drinks. If a person is unwilling to stop drinking altogether for the duration of the treatment, it is crucial to consult a doctor and determine the best course of action. In some instances, the benefits of Duloxetine will outweigh the risks of its interaction with spirits.
Frequently, however, it will be necessary to consider alternatives to Cymbalta and switch to a different medication. Spirits intensify Cymbalta side effects and how long they last.
These effects are similar to the symptoms that appear as a result of combining Cymbalta and gabapentin. Another significant issue is Cymbalta and alcohol cravings. While the drug is sometimes prescribed to help relieve the psychological effects of alcohol withdrawal , it can result in stronger cravings when misused.
In addition, the mix might also cause a Duloxetine overdose. The Duloxetine alcohol mix can induce more prolonged alcohol blackouts. Cymbalta is an antidepressant. Alcohol is a system depressant, too. So both of these substances alter brain function.
Unfortunately, what they both also do is affect the liver. Duloxetine can cause liver damage. Alcohol may contribute to an increase in mood-related symptoms or might even interfere with your treatment. If you are taking Cymbalta and want to know if it is safe to have a drink or two, talk to your doctor. Because they understand your situation and history, they can make recommendations based on your needs and health. They can also inform you about some of the potential dangers of mixing Cymbalta and alcohol.
These dangers are listed below. Both alcohol and Cymbalta can lead to liver damage. Taking these two substances together can heighten this risk. Your liver breaks down the substances you consume and removes toxins from your body. Because alcohol contains a number of toxins, chronic use can eventually overwork your liver and lead to liver damage. Cymbalta has also been linked to liver damage. According to the FDA's prescribing information for Cymbalta, the medication is not recommended for people who regularly consume alcohol.
People who have a history of liver problems or liver damage will have reduced metabolism of this medication. Some signs of potential liver damage include:. If you experience any of these symptoms while taking Cymbalta, you should contact your doctor immediately. Drug interactions can sometimes heighten the unwanted side effects of each substance. The FDA reports that when Cymbalta and alcohol are taken so that their peak effects coincide, the use of Cymbalta did not worsen the motor or mental impairment caused by alcohol.
Common side effects of Cymbalta include:. You may find that you experience such symptoms more acutely if you drink alcohol while you are taking Cymbalta. While Cymbalta is often prescribed to treat depression, it can destabilize mood in some instances. When combined with alcohol, it may also decrease the effectiveness of the medication.
This can lead to a worsening of symptoms of depression and anxiety. Some mood symptoms that might increase in severity as a result include:.
While it may seem like alcohol can lead to improvements in mood in the short term, it likely will contribute to an increase in mood symptoms such as depression and anxiety over the long term.
Children, teens, and young adults may also experience an increase in suicidal thoughts and behaviors, particularly when they first start taking Cymbalta.
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